Cytochrome P450-derived renal HETEs: storage and release.

We have established an assay based on gas chromatography-mass spectrometry to profile and quantitate endogenous cytochrome P450 monooxygenase (P450)-hydroxyeicosatetraenoic acids (HETEs) exiting the isolated perfused rabbit kidney in response to hormonal stimulation. In response to angiotensin II (Ang II) P450-derived HETEs (16-, 17-, 18-, 19- and 20-) are released from the isolated Kreb's perfused rabbit kidney. Ang II produced a several-fold increase in the levels of P450-HETEs above basal levels in both urinary (such as for 20-HETE from 0.

[Interhemispheric pharmacological asymmetry].

Based on primary change of the biochemistry of left hemisphere cortical neurons induced by aminazine and sodium bromide the conclusion is made about the presence of interhemispheric pharmacological asymmetry (IPA). The known data on the primary effect of alcohol on the right hemisphere are confirmed by the presence of the IPA.

[Comparative analysis of the effectiveness of standard and large dose fractionation in preoperative breast cancer irradiation].

The report deals with a retrospective comparison of the effectiveness of standard and large-fractionated preoperative radiation therapy of breast cancer patients (each group included 85 females). As a result of distant irradiation with daily single doses of 4 Gy (total dose--20 Gy), preoperative admission period was reduced 5--7 times, as compared with standard single doses of 2 Gy and total dosage of 40--45 Gy. Large--fractionated radiation therapy results in a relatively low incidence of general and local reactions, does not interfere with surgery and is followed by postoperative complications in fewer cases.