The CRAC channel inhibitor BTP2 restricts Tulane virus and human norovirus replication independent of store-operated calcium entry.

Unlabelled: Human norovirus is the leading cause of viral gastroenteritis across all age groups. While there is a need for human norovirus antivirals, therapeutic development has been hindered by a lack of cell culture systems and animal models of infection. Surrogate viruses, such as Tulane virus (TV), have provided tractable systems to screen potential antiviral compounds.

Active and direct patient participation in health professions education: A narrative overview of literature from the global south.

Objectives: Patients traditionally played a passive role in health professions education (HPE). However, their active involvement is increasingly valued, particularly in higher-resourced regions of the world known as the Global North. This study explores active and direct patient involvement in HPE contexts in the Global South (GS) regions of the world.

The influence of mood on the jumping to conclusions bias in individuals with schizotypal traits: an experience sampling paradigm.

The jumping to conclusions bias (JTC) refers to making a decision before collecting a sufficient amount of information to warrant doing so. Very little research has been conducted on the ways in which mood influences JTC in schizophrenia and healthy individuals along the continuum of risk for psychosis. It was hypothesized that elevations in schizotypal traits will be associated with greater JTC, and that negative affect will moderate the relationship between schizotypal traits and JTC.

A multicentre implementation trial of an Artificial Intelligence-driven biomarker to inform Shared decisions for androgen deprivation therapy in men undergoing prostate radiotherapy: the ASTuTE protocol.

Background: Androgen deprivation therapy (ADT) improves outcomes in men undergoing definitive radiotherapy for prostate cancer but carries significant toxicities. Clinical parameters alone are insufficient to accurately identify patients who will derive the most benefit, highlighting the need for improved patient selection tools to minimize unnecessary exposure to ADT's side effects while ensuring optimal oncological outcomes. The ArteraAI Prostate Test, incorporating a multimodal artificial intelligence (MMAI)-driven digital histopathology-based biomarker, offers prognostic and predictive information to aid in this selection.