Urinary calculi composition and its correlation with sex, age, calculi site, urine pH and underlying diseases: a retrospective study.

Objective: To investigate the composition of urinary calculi and its correlation with sex, age, calculi site, urine pH, and underlying diseases.

Methods: The clinical data of 300 patients with urinary calculi admitted to Meizhou People's Hospital from January 2022 to October 2024 were retrospectively analyzed. The composition of urinary calculi and its correlation with sex, age, calculi site, urine pH, and underlying diseases were examined.

Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma.

Approximately 80% of nasopharyngeal carcinoma (NPC) patients exhibit EGFR overexpression. The overexpression of EGFR has been linked to its potential role in modulating major histocompatibility complex class I (MHC-I) molecules. We discovered that EGFR, operating in a kinase-independent manner, played a role in stabilizing the expression of SLC7A11, which subsequently inhibited MHC-I antigen presentation.

Multi-omics dataset of individual variations in growth performance of large yellow croaker.

Large yellow croaker (Larimichthys crocea) is a highly economically important marine fish species in China. However, substantial individual variations in growth performance have emerged as a limiting factor for the sustainable development of the large yellow croaker industry. Gut microbiota plays a crucial role in fish growth and development by regulating metabolic processes.

Synergistic action of multiple degumming-related enzymes secreted by Bacillus subtilis XW-18: Decisive factor for driving the bio-degumming process of raw pineapple leaves.

Degumming, a process of removing gummy substances surrounding fiber, plays a crucial role in preparing plant fibers. This study clearly clarified that the multiple degumming enzymes by Bacillus subtilis XW-18 acted as a decisive factor for driving bio-degumming process of raw pineapple leaves. Firstly, PCR analysis verified that B.

AP2M1 as the potential biomarker for prediction of the response of atopic dermatitis to Dupilumab therapy: Multi-omics analysis and evidence.

Many atopic dermatitis (AD) patients have suboptimal responses to Dupilumab therapy. This study identified key genes linked to this resistance using multi-omics approaches to benefit more patients. We selected a prospective cohort of 54 CE treated with Dupilumab from the GEO database.