CCR5-ligand decorated rilpivirine lipid-based nanoparticles for sustained antiretroviral responses.

Antiretroviral therapy (ART) improves the quality of life for those living with the human immunodeficiency virus type one (HIV-1). However, poor compliance reduces ART effectiveness and leads to immune compromise, viral mutations, and disease co-morbidities. Here we develop a drug formulation in which a lipid-based nanoparticle (LBNP) carrying rilpivirine (RPV) is decorated with the C-C chemokine receptor type 5 (CCR5) targeting peptide.

A comprehensive review on nanoparticle-based photo acoustic: current application and future prospective.

In vivo, molecular imaging is prevalent for biology research and therapeutic practice. Among advanced imaging technologies, photoacoustic (PA) imaging and sensing is gaining interest around the globe due its exciting features like high resolution and good (~ few cm) penetration depth. PA imaging is a recent development in ultrasonic technology that generates acoustic waves by absorbing optical energy.

Regional differences in three-dimensional fiber organization, smooth muscle cell phenotype, and contractility in the pregnant mouse cervix.

The orientation and function of smooth muscle in the cervix may contribute to the important biomechanical properties that change during pregnancy. Thus, this study examined the three-dimensional structure, smooth muscle phenotype, and mechanical and contractile functions of the upper and lower cervix of nongravid (not pregnant) and gravid (pregnant) mice. In gravid cervix, we uncovered region-specific changes in the structure and organization of fiber tracts.

Synthesis of diarylsulphide-/diarylselenide-embedded pyrazole-fused isocoumarins and isatin/ninhydrin hydrazones acid-catalyzed solvent- and temperature-controlled reactions.

Room temperature stirring of a mixture of chalcogenated arylhydrazones and ninhydrin in dichloromethane (DCM) in the presence of acid leads to the formation of pyrazole-fused isocoumarins, substituted with a diarylsulphide/diarylselenide moiety. On the other hand, refluxing the same mixture in the protic polar solvent ethanol with acid produces diarylsulphide/diarylselenide containing ninhydrin hydrazones. Further study reveals that, like ninhydrin, isatin can also generate the corresponding chalcogenated hydrazones at the C-3 position under similar reaction conditions.