GNA15 induces drug resistance in B cell acute lymphoblastic leukemia by promoting fatty acid oxidation via activation of the AMPK pathway.

The prognosis of B cell acute lymphoblastic leukemia (B-ALL) is poor, primarily due to drug resistance and relapse. Ga15, encoded by GNA15, belongs to the G protein family, with G protein-coupled receptors playing a crucial role in multiple biological process. GNA15 has been reported to be involved in various malignancies; however, its potential role in B-ALL remain unknown.

Tuning Fork Scanning Electrochemical Cell Microscopy for Resolving Morphological and Redox Properties of Single Ag Nanowires.

We report a Tuning Fork Scanning Electrochemical Cell Microscopy (TF-SECCM) technique for providing morphological and electrochemical information on single redox-active entities. This new operation configuration of SECCM utilizes an electrolyte-filled nanopipette tip mounted onto a tuning fork force sensor to obtain a precise tip-sample distance control and surface morphological mapping capabilities. Redox activities of regions of interest (ROIs) can be investigated by scanning electrode potential by moving the nanopipette to any target regions while maintaining the constant force engagement of the tip with the sample.

Inhibition of IFITM3 in cerebrovascular endothelium alleviates Alzheimer's-related phenotypes.

Introduction: Interferon-induced transmembrane protein 3 (IFITM3) modulates γ-secretase in Alzheimer's Disease (AD). Although IFITM3 knockout reduces amyloid β protein (Aβ) production, its cell-specific effect on AD remains unclear.

Methods: Single nucleus RNA sequencing (snRNA-seq) was used to assess IFITM3 expression.

Metallic vanadium activated by an dissolution-deposition process for a superior aqueous zinc ion battery cathode.

Metallic vanadium is innovatively introduced for a superior aqueous zinc-ion battery cathode material, which is activated through dissolution-deposition transition to amorphous VO·3HO and delivers an excellent capacity of 610 mA h g at 0.1 A g and remarkable capacity retention rate of 80.3% after 1000 cycles at 1 A g.

Antisense mediated blockade of Dickkopf 1 attenuates tumor survival, metastases and bone damage in experimental osteosarcoma.

Osteosarcoma (OS) is the most common primary bone malignancy. The canonical Wnt inhibitor Dickkopf-1 (Dkk-1) has been implicated in bone destruction, tumor survival and metastases during OS. We examined the role of Dkk-1 in OS disease progression and explored strategies for targeting its activity.