Publications by authors named "S K P Konduru"
Randomized, open-label, phase 2 study of nivolumab plus ipilimumab or nivolumab monotherapy in patients with advanced or metastatic solid tumors of high tumor mutational burden.
J Immunother Cancer
August 2024
Article Synopsis
- Checkpoint inhibitor therapy, particularly nivolumab combined with ipilimumab, shows promise for patients with high tumor mutational burden (TMB-H) across various tumor types, indicating a potential survival benefit.
- The study involved 201 patients with advanced solid tumors who were resistant to standard treatments; they were randomly assigned to receive either the combination of nivolumab and ipilimumab or nivolumab alone, with the effectiveness measured based on objective response rates.
- Results demonstrated higher response rates in patients with TMB-H tumors who received the combination therapy, and the safety profile was acceptable, suggesting this treatment could be beneficial for patients with limited options.
Background: In the last 2 years of the pandemic, a wide range of cases of post-COVID functional gastrointestinal disorders (PC-FGIDs) has been reported.
Aim: This case series aimed to investigate the role of homeopathic intervention in the treatment of PC-FGIDs.
Methods: This is a retrospective analysis of the clinical data of individuals who had suffered from PC-FGIDs that were diagnosed based on clinical symptoms using the Gastrointestinal Symptoms Rating Scale (GSRS) and treated exclusively with individualized homeopathic medicines.
Treatment of severely hyponatremic patients with continuous renal replacement therapy (CRRT) presents a unique challenge given the lack of commercial options for hypotonic replacement solutions or dialysate. We report the case of a 55-year-old male who presented with profound, symptomatic hyponatremia in the setting of acute kidney injury (AKI). The patient was found to have a serum sodium concentration of 97 mEq/L because of free water retention that occurred during severe AKI from viral gastroenteritis and rhabdomyolysis.
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- Baclofen is a muscle relaxant that has been in use since 1977 and generally has few serious side effects when taken as prescribed.
- A case was reported where a 20-year-old woman developed catatonia after overdosing on baclofen, experiencing symptoms like aphasia and mutism after taking 200 mg following a suicide attempt.
- This is the first documented instance of baclofen-induced catatonia in a healthy individual, with past literature linking such episodes to prior psychotic symptoms; her condition improved with low-dose lorazepam treatment.
Study Objectives: Traumatic brain injury (TBI) can result in posttraumatic epilepsy (PTE) and sleep disturbances. We hypothesized that treatment with sleep aids after TBI can ameliorate PTE.
Methods: CD-1 mice underwent controlled cortical impact (CCI), sham injury, or no craniotomy.