Infants' diminished response to DTaP vaccine is associated with exposure to organophosphate esters.

Organophosphate esters (OPEs) are commonly applied as flame retardants and plasticizers. Toxicological studies suggest exposure effects on immune endpoints, raising concerns as infants' OPE exposures are elevated compared to older children and adults due to hand-to-mouth behavior and breastfeeding. Here, we sought to evaluate the immune responsiveness of infants to a neoantigen (e.

Regional and Local Temporal Trends of and spp. Seroprevalence in Domestic Dogs: Contiguous United States 2013-2019.

In 2019, in the United States, over 220,000 and 350,000 dogs tested positive for exposure to spp. and , respectively. To evaluate regional and local temporal trends of pathogen exposure we used a Bayesian spatio-temporal binomial regression model, analyzing serologic test results for these pathogens from January 2013 to December 2019.

Local and regional temporal trends (2013-2019) of canine Ehrlichia spp. seroprevalence in the USA.

Background: In the USA, there are several Ehrlichia spp. of concern including Ehrlichia canis, Ehrlichia ewingii, Ehrlichia chaffeensis, Ehrlichia muris eauclarensis, and "Panola Mountain Ehrlichia". Of these, E.

Serum procalcitonin concentrations in dogs with induced endotoxemia.

Background: Procalcitonin (PCT) is an important biomarker for sepsis in human medicine, but there is little information regarding PCT as a biomarker for sepsis in dogs. There are no controlled studies evaluating serial concentrations of PCT in dogs.

Hypothesis/objective: That PCT would be rapidly detectable in serum after injection of LPS and would remain increased for at least 24 hours.