Publications by authors named "S K Misser"

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Article Synopsis
  • Researchers studied brain MRI results in children suspected of having cerebral palsy to look for patterns similar to brain injuries caused by lack of oxygen.
  • They found that many conditions can look similar to these injuries, which can confuse doctors.
  • It's important for doctors, especially those reading the MRI results, to know about these other possible brain issues to help kids get the right care.
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Background: Injury patterns in hypoxic-ischaemic brain injury (HIBI) are well recognised but there are few studies evaluating cerebral injury using neuroquantification models.

Objectives: Quantification of brain volumes in a group of patients with clinically determined cerebral palsy.

Method: In this retrospective study, 297 children with cerebral palsy were imaged for suspected HIBI with analysis of various cerebral substrates.

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Background And Purpose: Considerable overlap exists in the MR imaging features of hypoglycemic injury and hypoxic-ischemic brain injury, with similar predilections for the occipital and parietal lobes. In partial, prolonged hypoxia-ischemia, there is cortical destruction at the interarterial watershed zones, and in concomitant hypoglycemia and hypoxia-ischemia, an exaggerated final common pathway injury occurs. We interrogated secondary white matter tract-based thalamic injury as a tool to separate pure injuries in each group.

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Aim: To describe the spectrum of parasagittal injury on MRI studies performed on children following severe perinatal term hypoxia-ischaemia, using a novel MRI grading system, and propose a new central pattern correlated with neuropathologic features.

Methods: MR scans of 297 patients with perinatal term hypoxia-ischaemia were evaluated for typical patterns of brain injury. A total of 83 patients that demonstrated the central/basal ganglia-thalamus and perirolandic pattern of injury were categorised according to the degree of severity.

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