Publications by authors named "S K Mahjoub"
Introduction: Immune checkpoint inhibitors (ICI) have improved the therapeutic arsenal in outpatient oncology care; however, data on necessity of hospitalizations associated with immune-related adverse events (irAEs) are scarce. Here, we characterized hospitalizations of patients undergoing ICI, from the prospective cohort study of the immune cooperative oncology group (ICOG) Hannover.
Methods: Between 12/2019 and 06/2022, 237 patients were included.
Endometriosis is a chronic, estrogen-dependent disorder associated with the presence of endometrial cells mainly in the pelvic cavity, causing systemic immune inflammation, infertility, epigenetic dysregulation of differential DNA methylation, coelomic metaplasia, and pain. It affects approximately 10-12% of women. Despite decades of research, full pathophysiology, a diagnostic roadmap, and clinical management strategies for endometriosis are not yet fully elucidated.
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- Platelet count is essential for clinical decisions, but the impedance technique (PLT-I) may overestimate counts in cases of microcytosis, prompting a comparison with the optical technique (PLT-O).
- A study analyzed blood samples with microcytosis (MCV<80 fL) and found a strong correlation between PLT-I and PLT-O for platelet values below 150 x 10^9/L, though a bias of 16.53 x 10^9/L was noted.
- The research suggests that while impedance can be used routinely, the optical technique should be used for samples with MCV<72.9 fL or when schizocytes are present to ensure accurate hemogram validation.
Introduction: Sirtuin1 (SIRT1) plays a crucial role in the pathophysiology of non-alcoholic fatty liver disease. We investigated the mechanistic role of galbanic acid (Gal) as a regulator of SIRT1 and .
Methods: HepG2 cells were treated with Gal in the presence or absence of EX-527, a SIRT1-specific inhibitor, for 24 h.
Introduction: Proximal femur fractures are one of the most common injuries in older adults representing a serious health condition in developed as well as developing countries.
Aim: This study aimed to assess the hospitalization costs of the proximal femur fracture.
Methods: We conducted a prospective descriptive study spread over six months about patients hospitalized and operated on for proximal femur fractures.