Publications by authors named "S K M van Zundert"
Article Synopsis
- Hypertensive disorders of pregnancy (HDP) are major contributors to complications in pregnancy, prompting research into the role of maternal tryptophan metabolites in placental health and development.
- The study involved 911 women and assessed serum tryptophan metabolites early in pregnancy, analyzing their relationships with placental volume and vascular development, as well as odds of developing HDP.
- Findings showed that higher kynurenine levels negatively impacted placental development, while increased levels of 5-hydroxytryptophan were linked to higher risks of early pregnancy hypertension and preeclampsia.
Article Synopsis
- - The study looks at whether stress hormones in pregnant women, called maternal vulnerability, can affect their baby's growth in the first trimester.
- - Researchers found that higher levels of certain stress hormones in hair were linked to slower growth of the baby, while another substance called tryptophan was lower when stress was higher.
- - The study used data from 132 pregnant women over a year to create a risk score for how vulnerable they are to stress and how it impacts their pregnancies.
Article Synopsis
- * Common causes of PIF include short bowel syndrome, neuromuscular disorders, and congenital enteropathies, with significant complications arising from HPN like infections and liver disease.
- * Advances in treatment, particularly through specialist care and new therapies like glucagon-like peptide 2, are improving outcomes, but ongoing research is needed to enhance care and prevent complications.
Background: The vital role of the maternal tryptophan (TRP) metabolism in maternal health and pregnancy is well established. However, non-medical maternal determinants influencing the TRP metabolism have been poorly investigated. We hypothesise that periconceptional maternal non-medical determinants alter the TRP metabolism, affecting both kynurenine (KP) and serotonin pathway (SP) metabolite concentrations.
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- - Higher levels of 5-hydroxytryptophan (5-HTP) in pregnant women are linked to lower embryonic and fetal growth, increasing the risk of being small-for-gestational age (SGA), while higher kynurenine (KYN) levels are associated with a lower risk of SGA.
- - Maternal tryptophan (TRP) metabolism plays an important role in the growth of embryos and fetuses, affecting both immune response and blood vessel function; disruptions in this metabolism can lead to negative outcomes for both mother and baby.
- - The study analyzed data from over 1,100 women using blood samples and advanced ultrasound techniques to track embryonic and fetal growth, employing various statistical models to