The Intra-Articular Delivery of a Low-Dose Adeno-Associated Virus-IL-1 Receptor Antagonist Vector Alleviates the Progress of Arthritis in an Osteoarthritis Rat Model.

Interleukin-1 (IL-1) is a pivotal mediator in the pathological progression of osteoarthritis (OA), playing a central role in disease progression. However, the rapid clearance of IL-1 receptor antagonist (IL-1Ra) from the joints may hinder the efficacy of intra-articular IL-1Ra injections in reducing OA-associated pain or cartilage degradation. Sustaining sufficient levels of IL-1Ra within the joints via adeno-associated virus (AAV)-mediated gene therapy presents a promising therapeutic strategy for OA.

Effect of Warming on Soil Fungal Community Along Altitude Gradients in a Subalpine Meadow.

The subalpine grassland ecosystem is sensitive to climatic changes. Previous studies investigated the effects of warming on grassland ecosystems at a single altitude, with little information about the response of subalpine meadows to warming along altitude gradients. This study aimed to evaluate the effects of warming on aboveground grass, belowground soil properties, and fungal community along altitude gradients in the subalpine meadow of Mount Wutai using the high-throughput sequencing method.

Diagnostic Accuracy of Antigen-Based Skin Tests (TBSTs) for Tuberculosis Infection Compared with TST and IGRA: A Network Meta-Analysis.

The aim of this study was to evaluate the diagnostic accuracy of the IGRA, TST, and TBST by combining diagnostic test accuracy (DTA) analysis and network meta-analysis (NMA) to increase the reliability and accuracy of diagnostic methods and promote the eradication of TB. An electronic search of the PubMed, Embase, and Cochrane databases was conducted, from the date of establishment to September 30, 2024. Data were synthesized with frequentist random-effects network meta-analyses, a single-group rate meta-analysis algorithm, and a bivariate mixed-effects logistic regression model.

Larval Feeding Habits of Five Firefly Species Across Aquatic, Semi-Aquatic, and Terrestrial Lineages.

While adult fireflies are terrestrial, their larvae inhabit various habitat types, and a lack of comprehensive research on the feeding habits of these larvae across different habitats has greatly impeded the development of artificial diets. Here, we tested 14 types of foods, primarily covering gastropods, vertebrates, and fruit, to survey feed for aquatic ( and ), semi-aquatic ( and sp.), and terrestrial () fireflies.

Parasitoids of Insect Pests Feeding on (Goodeniaceae) from Yongxing Island in South China Sea.

(Goodeniaceae) is an important evergreen coastal plant on islands in the South China Sea, which shows excellent tolerance for salty and drought conditions. Nevertheless, the growth of populations on these islands in the South China Sea has been threatened by a few serious insect pests. However, we know little about the biology of these pests.