[Neuroimmunopathological mechanisms of preclinical epileptogenesis and their correction by cycloferon].

The peculiarities of immunologic processes and immunocorrecting potential of Cyclopheron were studied in 62 patients with preclinical epileptogenesis. Using clinical, EEG and biochemical examination, expression of epileptogenesis was estimated as regressed, compensated, increasing, decompensated. Preclinical stage of epilepsy was accompanied by disturbance of immunological brain reactivity the expression of which was correlated with a level of compensative epileptogenesis manifestation.

[The optimization of epilepsy therapy with finlepsin].

A clinical pharmacological study (270 patients) was made to optimize therapy of epilepsy with carbamazepines (finlepsin and its retard form). It was established that insufficient (standard) doses of finlepsin are often used, serum levels of the drug are not estimated, drug pharmacokinetics is not taken into account, maximum permissible doses of the drug are not reached. Estimation of the efficiency of both preparations in the treatment of various types of the seizures was carried out.

[Fractal diagnostics of disturbances in the alpha-rhythm dynamics in patients with epilepsy].

A new method for analyzing the chaotic component of EEG is proposed. The method is based on estimating the fractal dimension of fluctuations of alpha-rhythm power (the square of amplitude). It is shown that the dimensions of the background EEG fragments for epilepsy patients is significantly higher than that in norm, indicating a disbalance of cerebral mechanisms that control the alpha-activity in this disease.

[Optimisation of epilepsy monotherapy (clinico-pharmacological study)].

The effect of four preparations (benzonal, phenobarbital, diphenyn, finlepsin), were examined in 214 epileptic patients with different forms of the fits. The advantages of monotherapy of epilepsy were grounded and therapeutic possibilities of the drugs were considered by means of clinico-pharmacological study. Standard and intensive methods of treatment of different forms of the fits were considered.