Fenofibrate ameliorates nitroglycerin-induced migraine in rats: Role of CGRP/p-CREB/P2X3 and NGF/PKC/ASIC3 signaling pathways.

Migraine, a debilitating neurological condition, significantly affects patients' quality of life. Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPAR-α) agonist approved for managing dyslipidemia, has shown promise in treating neurological disorders. Therefore, this study aims to investigate the protective effects of fenofibrate against nitroglycerin (NTG)-induced chronic migraine in rats.

Opportunities and challenges of tackling Scope 3 "Indirect" emissions from residential hot water.

The water sector could play a major role towards a Net Zero greenhouse gas (GHG) future if Scope 3 emissions were embraced and operationalised. Significant opportunities and challenges exist in tackling Scope 3 emissions including those associated with customer hot water use. Present GHG emission reduction practices predominantly focus on Scope 1 "within utility" and Scope 2 "purchased energy" emissions.

What roles do architectural design and on-site water servicing technologies play in the water performance of residential infill?

More than half of new urban residential developments are planned as infill in Australia's major cities. This provides an unprecedented opportunity to use innovative design and technology to address urban water challenges such as flooding, reduced water security and related infrastructure and urban heat island issues. However, infill can have positive or negative water impacts, depending on architectural design and on-site water servicing technologies implemented.

Site-scale Urban Water Mass Balance Assessment (SUWMBA) to quantify water performance of urban design-technology-environment configurations.

Historically, little consideration has been given to water performance of urban developments such as "hydrological naturalness" or "local water self-sufficiency". This has led to problems with increased stormwater runoff, flooding, and lack of local contributions to urban water security. Architectural design, water servicing technologies and environmental conditions are each known to influence water performance.

Global socio-economic losses and environmental gains from the Coronavirus pandemic.

On 3 April 2020, the Director-General of the WHO stated: "[COVID-19] is much more than a health crisis. We are all aware of the profound social and economic consequences of the pandemic (WHO, 2020)". Such consequences are the result of counter-measures such as lockdowns, and world-wide reductions in production and consumption, amplified by cascading impacts through international supply chains.