Publications by authors named "S K Jakaria Been Sayeed"
Article Synopsis
- The study investigates how cancer cells influence the fitness of surrounding tumor microenvironment (TME) cells through a mechanism involving a long non-coding RNA called Tu-Stroma, which alters the expression of Flower isoforms, impacting their growth advantage.
- The expression of Flower Win isoforms in cancer cells enhances their dominance over TME cells that express Flower Lose isoforms, leading to reduced fitness in the TME.
- Targeting Flower proteins with a humanized monoclonal antibody in mice has shown promising results, significantly reducing cancer growth and metastasis while improving survival rates and protecting organs from potential lesions.
Article Synopsis
- This study focuses on the ability of the Risk Analysis Index (RAI) and modified 5-item Frailty Index (mFI-5) to predict outcomes like extended length of stay, complications, and readmissions in patients undergoing spinal surgery for deformities.
- Researchers analyzed data from over 3,800 patients and found that both RAI and mFI-5 were significant predictors of longer hospital stays, with RAI being better for predicting readmissions and mFI-5 better for predicting complications.
- The results suggest that these frailty assessments can improve preoperative planning, but more research is needed to integrate these tools effectively in clinical practices.
Article Synopsis
- A study examined how opioid consumption affects hospital stay lengths after posterior spinal fusion in adolescents with idiopathic scoliosis, using data from the Premier Healthcare Database from 2016-2017.
- Patients were categorized based on their morphine milligram equivalent (MME) intake into Low, Medium, and High groups, with a focus on demographics, post-operative complications, and costs.
- Results showed that a higher opioid intake was linked to longer hospital stays, with 19.7% of High cohort patients experiencing extended stays compared to 6.5% of Low cohort patients, while the Low cohort faced higher admission costs.
Background: Risk Analysis Index (RAI) has been increasingly used to assess surgical frailty in various procedures, but its effectiveness in predicting mortality or in-patient hospital outcomes for spine surgery in metastatic disease remains unclear. The aim of this study was to compare the predictive values of the revised RAI (RAI-rev), the modified frailty index-5 (mFI-5), and advanced age for extended length of stay, 30-day readmission, complications, and mortality among patients undergoing spine surgery for metastatic spinal tumors.
Methods: A retrospective cohort study was performed using the 2012-2022 ACS NSQIP database to identify adult patients who underwent spinal surgery for metastatic spinal pathologies.