Dual targeting of the mitochondrial Lon peptidase 1 and the chymotrypsin-like proteasome activity as a potential therapeutic strategy in malignant astrocytoma models.

Malignant astrocytomas are aggressive primary brain tumors characterized by extensive hypoxia-induced, mitochondria-dependent changes such as altered respiration, increased chymotrypsin-like (CT-L) proteasome activity, decreased apoptosis, drug resistance, stemness, and increased invasiveness. Mitochondrial Lon Peptidase 1 (LonP1) overexpression and increased CT-L proteasome activity are biomarkers of an aggressive high-grade phenotype and found to be associated with recurrence and poor patient survival. In preclinical models, small molecule agents targeting either LonP1 or the proteasome CT-L activity have anti-astrocytoma activity.

Survey on the impact of WHO 2021 classification of brain tumors on adult glioma management in Africo-Asian region.

The 2021 WHO classification of central nervous system (CNS) tumors introduced significant changes based on molecular and biological tumor characteristics, aiming to improve prognostication and enable more precise treatment approaches. This study investigated the awareness, adoption, and impact of the new classification on adult glioma management among healthcare professionals in Africo-Asian region. Through a structured survey questionnaire distributed across these regions, assessment of the level of awareness, diagnostic changes, challenges faced, and future perspectives among respondents was done.

Designing novel cabozantinib analogues as p-glycoprotein inhibitors to target cancer cell resistance using molecular docking study, ADMET screening, bioisosteric approach, and molecular dynamics simulations.

Introduction: One of the foremost contributors to mortality worldwide is cancer. Chemotherapy remains the principal strategy for cancer treatment. A significant factor leading to the failure of cancer chemotherapy is the phenomenon of multidrug resistance (MDR) in cancer cells.

CAG Repeat Instability and Region-Specific Gene Expression Changes in the SCA12 Brain.

Spinocerebellar ataxia type 12 (SCA12), an autosomal dominant cerebellar ataxia, caused by an expansion of (CAG) in the 5' of the PPP2R2B gene on chr5q32, is common in India. The illness often manifests late in life, with diverse neurological and psychiatric symptoms, suggesting involvement of different brain regions. Prominent neuronal loss and atrophy of the cerebellum have been noted earlier.

Small-angle vertical strabismus treatment in the elderly.

Small vertical fusion amplitudes complicate the management of small-angle vertical strabismus in the elderly, and innovative procedures have the potential to facilitate effective treatment options in these patients. To identify and evaluate alternative procedures for the treatment of small-angle vertical strabismus in the elderly, we conducted a comprehensive literature search in PubMed and Google Scholar. Here, we identify and evaluate new surgical techniques that target small-angle vertical strabismus, including graded partial tenotomy, partial tendon recession, minitenotomy, and miniplication.