Well-differentiated papillary mesothelioma found incidentally with concurrent struma ovarii: A case report.

This is the first report of well-differentiated papillary mesothelioma (WDPM) found concurrently with struma ovarii. These rare tumors have no know association, and are considered benign, though malignant transformation of WDPM has been described. After treatment of WDPM, follow-up surveillance has been suggested in the literature, though a method has not been described and an evidence base is lacking.

Tramadol and o-desmethyl tramadol clearance maturation and disposition in humans: a pooled pharmacokinetic study.

Background And Objectives: We aimed to study the impact of size, maturation and cytochrome P450 2D6 (CYP2D6) genotype activity score as predictors of intravenous tramadol disposition.

Methods: Tramadol and O-desmethyl tramadol (M1) observations in 295 human subjects (postmenstrual age 25 weeks to 84.8 years, weight 0.

The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3.

PR-104, currently in phase II clinical trials, is a phosphate ester pre-prodrug which is converted in vivo to its cognate alcohol, PR-104A, a prodrug designed to exploit tumor hypoxia. Bioactivation occurs via one-electron reduction to DNA crosslinking metabolites in the absence of oxygen. However, certain tumor cell lines activate PR-104A in the presence of oxygen, suggesting the existence of an aerobic nitroreductase.