Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns.

Background: Gestational exposure to non-persistent endocrine-disrupting chemicals (EDCs) may be associated with adverse pregnancy outcomes. While many EDCs affect the endocrine system, their effects on endocrine-related metabolic pathways remain unclear. This study aims to explore the global metabolome changes associated with EDC biomarkers at delivery.

Adaptive neural observer-based output feedback anti-actuator fault control of a nonlinear electro-hydraulic system with full state constraints.

This paper proposes an adaptive output feedback full state constrain (FSC) controller based on the adaptive neural disturbance observer (ANDO) for a nonlinear electro-hydraulic system (NEHS) with unmodeled dynamics. The Barrier Lyapunov Functions (BLFs) are utilized to ensure that all states of the system are specified within the constraints, and the approximation ability of radial basis function neural networks (RBFNNs) is used to cope with the unknown nonlinear functions. An adaptive neural compensation disturbance observer is elaborated to estimate the compound disturbance and oil leakage fault, effectively addressing these negative effects.

A pre- and post-course survey of an elective Chinese medicine curriculum among junior Western medical students in Taiwan.

Background: Demonstrating a positive impact of educational programs on clinical care outcomes is challenging. We assess students' knowledge, attitudes, and behaviors as short-term outcomes of integrating a structured Traditional Chinese Medicine course within a Western medical school.

Methods: A prospective questionnaire survey was conducted among first-year and second-year undergraduate medical students who participated in the "Introduction to Chinese Medicine" course in 2020.

Assessment of blended learning palliative care educational programme in cancer treatment centres in India.

Objectives: The study evaluates the fifth cohort of the palliative care cancer treatment centres (CTC) educational programme in India with the aim of refining the course on the basis of participant feedback thereby improving palliative care services at cancer centres.

Methods: The intervention included participation in the CTC 5 teaching and training programme, which encompassed foundation course, refresher course, access to palliative care training modules, clinical training and mentorship under palliative care experts. The feedback was taken from all 57 participants (29 doctors and 28 nurses) of CTC 5 programme representing 14 hospitals across nine regions in India.

Effects of bone metabolism on hematopoiesis: A Mendelian randomization study.

Objectives: Osteoblast is known to regulate hematopoiesis according to preclinical studies but the causal relationship in human remains uncertain. We aimed to evaluate causal relationships of bone mineral density (BMD) with blood cell traits using genetic data.

Methods: Summary statistics from the largest available genome-wide association study were retrieved for total body BMD (TBBMD), lumbar spine BMD (LSBMD), femoral neck BMD (FNBMD) and 29 blood cell traits including red blood cell, white blood cell and platelet-related traits.