Publications by authors named "S K Hietala"
Development of Amniotic Epithelial Stem Cells Secretome-Loaded Inverse Electron Demand Diels-Alder-Cross-Linked Hydrogel as a Potential Immunomodulatory Therapeutical Tool.
ACS Appl Mater Interfaces
January 2025
Article Synopsis
- Amniotic epithelial stem cells (AEC) have regenerative potential, particularly through their conditioned medium (AEC-CM), which shows immunomodulatory and regenerative effects.
- A novel hydrogel made from hyaluronic acid and polyethylene glycol was developed to encapsulate AEC-CM, with features like fast cross-linking and sustained growth factor release over 14 days.
- Studies demonstrate that the encapsulated AEC-CM significantly enhances the suppression of peripheral blood mononuclear cells and promotes a shift towards the beneficial M2 macrophage phenotype, suggesting its viability as an immunomodulatory treatment for tissue regeneration.
Improving the solubility of poorly water-soluble drugs is essential for enhancing bioavailability, formulation flexibility and reducing patient-to-patient variability. The preparation of amorphous solid dispersions (ASDs) is an attractive strategy to formulate such drugs, leading to higher apparent water solubility and therefore higher bioavailability. For such ASDs, water-soluble polymer excipients, such as poly(vinyl pyrrolidone) (PVP) or poly(vinyl pyrrolidone-co-vinyl acetate) (P(VP-co-VA)), are employed to solubilize and stabilize the drug against crystallization.
View Article and Find Full Text PDFGlucuronoxylans (GX), particularly crude fractions obtained by pressurized hot water extraction of birch wood, act as potent emulsifiers and stabilizers against physical separation and lipid oxidation. Herein, we studied the adsorption of GX on hydrophobic interfaces to correlate their multicomponent character towards the formation of interfacial layers in emulsions. Dynamic interfacial tension (DIFT) and quartz crystal microgravimetry with dissipation monitoring (QCM-D) were applied to various GX fractions and the results compared with those from cellulose-based emulsifiers.
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- The study investigates how dodecylamine interacts with reducing end groups in cellulose nanocrystals.
- Using solution-state NMR, researchers demonstrated a specific reaction that leads to the creation of glucosylamines.
- This method offers a sustainable way to functionalize bio-based nanomaterials without needing additional steps to make them more stable.
Microfluidic on-chip production of polymeric hydrogel microspheres (MPs) can be designed for the loading of different biologically active cargos and living cells. Among different gelation strategies, ionically crosslinked microspheres generally show limited mechanical properties, meanwhile covalently crosslinked microspheres often require the use of crosslinking agents or initiators with limited biocompatibility. Inverse electron demand Diels Alder (iEDDA) click chemistry is a promising covalent crosslinking method with fast kinetics, high chemoselectivity, high efficiency and no cross-reactivity.
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