Publications by authors named "S K Hayath Basha"
Introduction: The marine habitat is a plentiful source of diverse, active compounds that are extensively utilised for their medicinal properties. Pharmaceutical trends have currently changed towards utilising a diverse range of goods derived from the marine environment.
Method: This study aimed to examine the inhibitory effects of bioactive chemicals derived from marine algae and bacteria.
As developers and practitioners translate parenting interventions from research to practice, significant heterogeneity in provider fidelity and parent engagement with the program has contributed to observed declines in intervention effectiveness. Despite this, empirical investigations of the relationship between provider fidelity, parent engagement, and intervention outcomes are scarce and those that exist show discrepant outcomes. This is, in part, due to the variability in the way fidelity is defined, operationalized, and measured.
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- Archaeal group II chaperonins, or heat shock proteins (HSPs), are crucial for protein folding and protection during thermal stress in Sulfolobales, especially when faced with thermal shock.
- HSPs maintain structural integrity at neutral pH and varying temperatures but show significant changes at ultra-low pH (pH 2), with HSPα and HSPβ being more thermostable than HSPβ-coh.
- Molecular dynamics simulations support lab findings, revealing stability differences among HSP subtypes and highlighting limitations in acid tolerance despite their thermal resilience.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by cognitive decline, memory impairment, and behavioral alterations. The N-methyl-D-aspartate (NMDA) receptor has emerged as a promising target for AD pharmacotherapy due to its role in the disease's pathogenesis. This study leverages advanced computational methods to screen 80 active constituents of Withania somnifera (Ashwagandha), a traditional herb known for its neuroprotective effects, against the NMDA receptor, using FDA-approved Ifenprodil as a reference.
View Article and Find Full Text PDFAim: This study aimed to evaluate the impact of silibinin as a therapeutic agent on ligature-induced periodontitis in rats with liver cirrhosis.
Materials And Methods: Twenty-five Wistar rats were enrolled in this study. Group A (Control) included eight rats.