The prevalence of primary chronic rhinosinusitis in young adults from a Swedish birth cohort.

Background: Chronic rhinosinusitis (CRS) is common worldwide but scarcely studied among young adults. The aim was to investigate prevalence, clinical features, comorbidity, and mucosal inflammatory patterns of CRS among 24-year-olds in a populationbased study.

Method: 3037 subjects from the birth cohort BAMSE (Barn/children Allergy Milieu Stockholm Epidemiology) had complete questionnaire answers on CRS at the 24-year-follow-up.

Upregulated expression of Notch1/4 - JAG-1/DLL-1 detected in allergic rhinitis.

Background: Allergic rhinitis (AR) is a chronic disease with high prevalence. There are currently many treatments available. However, despite an often good therapeutic response, many patients still report impairment in quality of life (QoL) during the pollen season.

Regulatory B cells producing IL-10 are increased in human tumor draining lymph nodes.

The contribution of different immune cell subsets, especially T cells, in anti-tumor immune response is well established. In contrast to T cells, the anti-tumor contribution of B cells has been scarcely investigated. B-cells are often overlooked, even though they are important players in a fully integrated immune response and constitute a substantial fraction of tumor draining lymph nodes (TDLNs) known also as Sentinel Nodes.

Sentinel node-assisted neck dissection in advanced oral squamous cell carcinoma-A new protocol for staging and treatment.

Background: Sentinel lymph node biopsy (SLNB) is used to improve the staging of and guide treatment in patients with early-stage T1-T2 N0 oral squamous cell carcinoma (OSCC). The role of sentinel nodes (SNs) and the use of SN-technique in advanced OSCC (T3-T4 and/or N+) remain to be evaluated. This study investigates the nodal drainage and the rate of positive SNs (SNs+) in all stages of OSCC.