Publications by authors named "S K Gambhir"
Objective: This study aims to assess the role of 18F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) in suspected recurrent ovarian carcinoma. Several clinical and PET parameters were assessed to evaluate disease burden and prognosis.
Methods: We did a single-center, retrospective study in patients with suspected recurrent ovarian carcinoma who underwent 18F-FDG PET/CT.
Circulating tumor cells (CTCs) are associated with tumor burden and treatment response and, as hallmarks of the initiation of tumor dissemination, can predict the likelihood of metastatic progression before widespread tumors can be detected by standard anatomic imaging. However, early diagnosis of recurrence through the detection of CTCs is limited by their low prevalence in blood and the limited sensitivity of existing technologies. To address these challenges, we investigated the use of ultrasound and targeted microbubbles (MBs) for early CTC detection.
View Article and Find Full Text PDFBackground: Differentiated thyroid carcinoma (DTC) is managed by surgery followed by radioiodine (RAI) therapy in most intermediate and high-risk patients. Most nonmetastatic patients have excellent treatment responses and have long-term disease-free status. A lack of comprehensive medical services in resource-limited nation leads to attrition of critical clinical prognostication information.
View Article and Find Full Text PDFIntroduction: Diagnosing cardiac sarcoidosis (CS) is challenging due to the lack of a sensitive gold standard diagnostic test. Although advanced imaging techniques like cardiac magnetic resonance imaging (MRI) (cardiovascular magnetic resonance [CMR]) and fluorodeoxyglucose positron emission tomography (FDG-PET) CT are promising, they are limited by their availability and cost. Two-dimensional speckle-tracking echocardiography (2D-STE) is emerging as a valuable tool for the early detection of CS.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effectiveness of technetium-99m-labeled PSMA SPECT/CT as a potential cost-effective alternative to gallium-68 PSMA PET/CT for detecting biochemical recurrence in prostate cancer with low PSA levels.
- 25 patients with biochemical recurrence underwent both imaging modalities, revealing similar disease distribution and metastatic burden.
- Although Tc-PSMA SPECT/CT showed good concordance with Ga-PSMA PET/CT, some patients with small-sized lymph nodes were understaged with Tc-PSMA, highlighting a limitation in its sensitivity.