A retrospective multicenter study on the efficacy and safety of disitamab vedotin monotherapy versus combination with anti-PD-1 immunotherapy in advanced gastric cancer.

Novel therapeutic agents including disitamab vedotin (RC48, an antibody-drug conjugate) and immune-checkpoint inhibitors (e.g., PD-1 inhibitors) have provided new hope as an advanced gastric-cancer (GC) treatment.

Reversible Sol-Gel Transitions Mediated Organics Selective Uptake and Release for Simultaneous Water Purification and Chemicals Recovery.

The separation and recovery of useful organics from wastewater have been a promising alternative to tackling water pollution and resource shortages, while strategies that truly work have rarely been explored. Herein, a reversible CO triggered sol-gel state transformation mediated selective organics uptake-release system using a surface modified carbonitride (S-CN) is proposed and exhibits remarkable organics recovery performance from wastewater. Results show that CO can serve as a cross-linker for linking S-CN particles to form a hydrogel by electrostatic interaction and hydrogen bonding, which can be recycled to the pristine sol state simply by removing the cross-linked CO with Ar purging.

In Vitro Cholesterol-Lowering Bioactivity, Synthetic Pathway, and Structural Characterization of Exopolysaccharide Synthesized by Z171.

A strain identified as was isolated from Chinese sauerkraut, and its exopolysaccharide (EPS) exhibited excellent in vitro cholesterol-lowering bioactivity. Besides, the whole genome of this strain and the structure characteristics of the purified EPS were investigated in this study. Z171 presented a strong EPS production capacity, with five nucleotide sugar biosynthesis pathways regulated by an EPS synthesis gene cluster.

Observation of single-photon azimuthal backflow with weak measurement.

Quantum backflow (QB), a counterintuitive interference phenomenon where particles with positive momentum can propagate backward, is important in applications involving light-matter interactions. To date, experimental demonstrations of backflow have been restricted to classical optical systems using techniques such as slit scanning or Shack-Hartmann wavefront sensing, which suffer from low spatial resolution due to the inherent limitations in slit width and lenslet array density. Here, we report an observation of azimuthal backflow (AB) both theoretically and experimentally by employing the weak measurement technique, which enables the precise extraction of photon momentum at each pixel.