Comparing integrative ventilatory and renal acid-base acclimatization in lowlanders and Tibetan highlanders during ascent to 4,300 m.

With over 14 million people living above 3,500 m, the study of acclimatization and adaptation to high altitude in human populations is of increasing importance, where exposure to high altitude (HA) imposes a blood oxygenation and acid-base challenge. A sustained and augmented hypoxic ventilatory response protects oxygenation through ventilatory acclimatization, but elicits hypocapnia and respiratory alkalosis. A subsequent renally mediated compensatory metabolic acidosis corrects pH toward baseline values, with a high degree of interindividual variability.

Thyroidea Ima Artery in Cadavers of a Medical College in Nepal: A Descriptive Cross-sectional Study.

Introduction: Thyroidea ima artery is a variant arterial branch of arch of aorta supplying the thyroid gland. Understanding the anatomic variances and correctly identifying the thyroidea ima artery is crucial to preventing serious complications both before and after neck surgery. The aim of this study was to find out the prevalence of thyroidea ima artery in cadavers of a medical college in Nepal.

Occurrence of biofilm forming Escherichia coli in drinking water supply system in Kathmandu.

Biofilm development in gram negative bacterial contaminants in water supply systems is linked to persistence as well as antibiotic resistance, which threatens water quality and hence the public health. This study aimed to investigate phenotypic and genetic capacity of biofilm formation by Escherichia coli isolated from supply water with their antibiotic susceptibility pattern. Altogether fifty water samples collected from a city supply water distribution scheme in Kathmandu were analyzed to assess the physicochemical and microbiological quality.