Publications by authors named "S K Brandt"
Introduction: Previous randomised controlled trials (RCTs) have indicated a protective role of pregnancy supplementation with fish oil and high-dose vitamin D, respectively, on offspring asthma, infections and several other disorders in early childhood. However, current evidence is not considered sufficient for recommending these supplements in pregnancy. In two RCTs, we aim to investigate whether these protective effects can be confirmed in larger trials with the goal of changing clinical practice and improving child health.
View Article and Find Full Text PDFHoney bee foraging is a complex behavior because it involves tens of thousands of organisms making decisions about where to collect pollen and nectar based on the quality of resources and the distance to flowers. Studying this aspect of their biology is possible through direct observations but the large number of individuals involved in this behavior makes the implementation of technologies ideal to scale up this type of study. Consequently, there is a need for instruments that can facilitate accurate assessments of honey bee foraging at the colony level.
View Article and Find Full Text PDFLong term effects of aromatase inhibitor treatment in patients with aromatase excess syndrome.
Front Endocrinol (Lausanne)
December 2024
Article Synopsis
- Aromatase excess syndrome (AEXS) is a rare genetic disorder that leads to excessive conversion of androgens to estrogens, causing issues like gynecomastia and delayed puberty in males, and fewer cases reported in females.
- A family study revealed that all four members with AEXS shared a specific genetic deletion, and the long-term use of aromatase inhibitors like letrozole improved symptoms such as accelerated growth and gynecomastia.
- Treatment outcomes varied among family members: significant gains in adult height and reduction of gynecomastia were noted in the male patients, while the female sibling experienced normal puberty development and growth with a combination of therapies.*
The classical psychedelic drug (+)-lysergic acid diethylamide (LSD) continues to attract considerable multidisciplinary interest, and over the last eight decades, many derivatives and analogs of LSD have been synthesized. One site on the ergoline scaffold of LSD that has been frequently modified is the N-position, with the N-acylated LSD derivative 1-acetyl-LSD (1A-LSD, ALD-52) being one of the earliest examples. In more recent years, several other alkylcarbonyl- and cycloalkylcarbonyl-substituted LSD derivatives have been evaluated, including several distributed as research chemicals.
View Article and Find Full Text PDFArticle Synopsis
- Upper urinary tract urothelial tumors are commonly treated with endoscopic laser ablation, especially if they are low grade and non-invasive.
- The study analyzed 118 patients who underwent this treatment from 2012 to 2022, recording their characteristics and outcomes.
- Results indicated a high recurrence rate within the first three years post-treatment, but overall survival and disease-specific survival rates were relatively high, suggesting laser ablation is a safe option despite the need for regular follow-ups.