Publications by authors named "S K Amarnath"
Regulatory T cells (Tregs) are immune regulatory T cells that are vital for controlling inflammation. The role of Tregs in inflammatory diseases namely psoriatic arthritis (PsA) is still poorly understood. The underlying reason being a lack of robust unbiased analysis to test the immune regulatory phenotype of human Tregs.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates whether early restaging with endoscopy and MRI after induction therapy in rectal cancer patients influences the final treatment outcome.
- - Analyzed data from 107 patients showed that those with better interim responses had significantly higher chances of achieving complete final responses, highlighting a potential link between early assessment and ultimate success.
- - Limitations of the study include its retrospective nature and small sample size, which might affect the reliability of the findings, particularly regarding the implications of partial responses.
Background: Total neoadjuvant therapy in the treatment of stage II and III rectal cancer involves the administration of either induction or consolidation chemotherapy with chemoradiation before surgery. Total neoadjuvant therapy is associated with an increased complete response rate, which is defined as the proportion of patients who either had a pathological complete response after surgery or sustained a clinical complete response for at least 1 year under surveillance.
Objective: To identify the predictors of complete response to total neoadjuvant therapy and compare different diagnostic tools in predicting complete response.
Article Synopsis
- - Inflammatory myofibroblastic tumors (IMTs) are intermediate malignant mesenchymal tumors that are uncommon in the stomach, primarily affecting young adults, and are often misdiagnosed as other types of tumors.
- - The exact cause of IMTs is not well understood, but it's believed to arise from an exaggerated inflammatory reaction to chronic infections.
- - A case is presented involving a middle-aged woman with a gastric mass who underwent several endoscopic procedures, but her definitive diagnosis of gastric IMT was only achieved after partial gastrectomy and specific immunohistochemistry testing.