Publications by authors named "S K Afridi"
Article Synopsis
- The study investigates the genetic diversity of malaria parasites, specifically focusing on the Pfmsp1 and Pfmsp2 genes in Plasmodium falciparum and the Pvmsp-3α gene in Plasmodium vivax from Nowshera District, Pakistan.
- Blood samples from 124 malaria patients were collected and analyzed using genomic techniques, uncovering numerous distinct alleles and variants in both P. falciparum (21 alleles) and P. vivax (4 allelic variants).
- The findings indicate moderate to high allelic diversity among the malaria parasites in the area, marking the first molecular characterization of these genotypes in this specific region.
Article Synopsis
- * The study identified PD-L1 expression as a potential prognostic biomarker by examining tissue samples from 86 pancreatic cancer patients, linking PD-L1 levels to tumor characteristics and overall survival.
- * High levels of PD-L1 were correlated with increased disease aggression and shorter survival times, suggesting that PD-L1 could play a significant role in the diagnosis and treatment of pancreatic cancer.
Article Synopsis
- PvDBP is essential for the malaria parasite Plasmodium vivax to invade red blood cells by binding to a receptor called DARC, and its amino-terminal region II (PvDBPII) shows potential as a vaccine target.
- A study of 118 P. vivax isolates from Pakistan identified 29 single nucleotide polymorphisms (SNPs), mainly in subdomains II and III of PvDBPII, with a notable 22 being nonsynonymous, indicating significant genetic variation.
- Despite variation in amino acid changes between countries, both nucleotide diversity and patterns of natural selection in the Pakistan isolates align with those found globally, providing critical insights for developing effective vaccines against vivax malaria.
Article Synopsis
- Over one-third of patients with migraines experience inadequate relief from acute medications, highlighting the need for more effective treatments.
- Sumatriptan-naproxen sodium, a combined medication, was studied in 14 clinical trials to assess its effectiveness for migraine relief among adults and adolescents.
- The results showed that sumatriptan-naproxen sodium provided significantly superior pain relief within 2 hours and sustained pain freedom for up to 24 hours compared to other treatments, demonstrating its potential in enhancing acute migraine care.
Plasmodium vivax variant interspersed repeats (vir) refer to the key protein used for escaping the host immune system. Knowledge in the genetic variation of vir genes can be used for the development of vaccines or diagnostic methods. Therefore, we evaluated the genetic diversity of the vir genes of P.
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