Iron Availability within the Leaf Vasculature Determines the Magnitude of Iron Deficiency Responses in Source and Sink Tissues in Arabidopsis.

Iron (Fe) uptake and translocation in plants are fine-tuned by complex mechanisms that are not yet fully understood. In Arabidopsis thaliana, local regulation of Fe homeostasis at the root level has been extensively studied and is better understood than the systemic shoot-to-root regulation. While the root system is solely a sink tissue that depends on photosynthates translocated from source tissues, the shoot system is a more complex tissue, where sink and source tissues occur synchronously.

Development and biodistribution studies of As-labeled trithiol RM2 bioconjugates for prostate cancer: Comparison of [As]As-trithiol-Ser-Ser-RM2 vs. [As]As-trithiol-Glu-Ser-RM2.

Introduction: Recent progress with the production of As (2.49 Mev β (64%), 3.33 Mev β (16%), 834 keV γ (81%), t: 26 h) and As (0.

A Third Generation Potentially Bifunctional Trithiol Chelate, Its Sb(III) Complex, and Selective Chelation of Radioantimony (Sb) from Its Sn Target.

The therapeutic potential of the Meitner-Auger- and conversion-electron emitting radionuclide Sb remains unexplored because of the difficulty of incorporating it into biologically targeted compounds. To address this challenge, we report the development of Sb production from electroplated tin cyclotron targets and its complexation by a novel trithiol chelate. The chelation reaction occurs in harsh solvent conditions even in the presence of large quantities of tin, which are necessary for production on small, low energy (16 MeV) cyclotrons.

Recovery, recycling and re-irradiation of enriched Ru metal targets for cost effective production of Rh.

Rhodium-105 (0.567 MeV β, 319 keV γ, 35.4 h half-life) was produced by neutron irradiation of enriched Ru (>99%) over multiple decades.

Direct labeling of a somatostatin receptor antagonist via peptide cyclization with Re, Tc and Re metal centers: Radiochemistry and in vitro evaluation.

Introduction: With the long-term goal of developing a diagnostic (Tc) and therapeutic (Re) agent pair for targeting somatostatin receptor (SSTR)-positive neuroendocrine tumors (NETs), we developed novel metal-cyclized peptides through direct labeling of the potent SSTR2 antagonist Ac-4-NO-Phe-c(DCys-Tyr-DTrp-Lys-Thr-Cys)-DTyr-NH (1) with Re (in Re-1), Tc (in [Tc]Tc-1) and Re (in [Re]Re-1).

Methods: Re-1 was characterized by LC-ESI-MS and HR-ESI-MS and was tested for receptor affinity in SSTR-expressing cells (AR42J). Radiolabeling of the peptide was achieved via ligand exchange from Tc-labeled glucoheptonate or [Re]ReOCl(PPh), yielding [Tc]Tc-1 or [Re]Re-1, respectively.