Publications by authors named "S Junius"
The tissues are the site of many important immunological reactions, yet how the immune system is controlled at these sites remains opaque. Recent studies have identified Foxp3 regulatory T (Treg) cells in non-lymphoid tissues with unique characteristics compared with lymphoid Treg cells. However, tissue Treg cells have not been considered holistically across tissues.
View Article and Find Full Text PDFFOXP3-expressing regulatory T cells (T ) are indispensable for immune homeostasis and tolerance, and in addition tissue-resident T have been found to perform noncanonical, tissue-specific functions. For optimal tolerogenic function during inflammatory disease, T are equipped with mechanisms that assure lineage stability. T lineage stability is closely linked to the installation and maintenance of a lineage-specific epigenetic landscape, specifically a T -specific DNA demethylation pattern.
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- The absence of T cell infiltration in tumors presents a challenge for successful cancer immunotherapy, while the presence of tumor-associated lymphoid structures (TA-TLLSs) indicates a better chance of patient recovery.
- Recent research shows that antiangiogenic therapies can transform blood vessels in tumors into specialized structures (HEVs) that support immune cell activity through specific signaling pathways.
- These tumor-derived HEVs promote the entry of immune cells, creating favorable conditions for CD8 T cell development, and their existence relies on ongoing signals from immune cells, highlighting a dynamic relationship between tumors and the immune system.