Publications by authors named "S Juma"
Contraction of heart muscle requires activation of both the actin and myosin filaments. The mechanism of myosin filament activation is unknown, but the leading candidate hypothesis is direct mechano-sensing by the filaments. Here, we tested this hypothesis by activating intact trabeculae from rat heart by electrical stimulation under different loads and measuring myosin filament activation by X-ray diffraction.
View Article and Find Full Text PDFBackground: In the fall of 2020, the COVID-19 infodemic began to affect public confidence in and demand for COVID-19 vaccines in the United States. While polls indicated what consumers felt regarding COVID-19 vaccines, they did not provide an understanding of why they felt that way or the social and informational influences that factored into vaccine confidence and uptake. It was essential for us to better understand how information ecosystems were affecting the confidence in and demand for COVID-19 vaccines in the United States.
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- Schistosomiasis is a significant health challenge in sub-Saharan Africa, where 95% of global cases are found, leading to an increased demand for praziquantel (PZQ) for treatment among all age groups at risk.
- The study analyzed research from 1991 to 2022 to determine the relationship between the prevalence of schistosomiasis in humans and its presence in intermediate snail hosts, using a statistical model for pooled prevalence estimates.
- Results indicated that schistosomiasis affects about 27.5% of humans, with certain snail species demonstrating infection rates of 8.6%, and a modest correlation (0.3) was found between infections in snails and humans, suggesting snails could
Background: After decades of praziquantel mass drug administration (MDA), several countries approach schistosomiasis elimination. Continuing MDA in largely uninfected populations no longer seems justified. Alternative interventions to maintain the gains or accelerate interruption of transmission are needed.
View Article and Find Full Text PDFOsteoarthritis and psoriasis arthritis are two degenerative forms of arthritis that share similar yet also different manifestations at the histological, cellular, and clinical levels. Rheumatologists have marked them as two entirely distinct arthropathies. Given recent discoveries in disease initiation and progression, potential mechanisms, cellular signaling pathways, and ongoing clinical therapeutics, there are now more opportunities for discovering osteoarthritis drugs.
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