Publications by authors named "S Jukarainen"
Article Synopsis
- In Finland, isolated cleft palate (CP) occurs more frequently than cleft lip with or without cleft palate (CL/P), which is the opposite trend seen in other European countries.
- A genome-wide association study revealed a specific single nucleotide polymorphism (rs570516915) strongly linked to CP in the Finnish population, showing significant statistical results and confirmed in other cohorts.
- The risk allele for rs570516915 disrupts a binding site for the IRF6 transcription factor, leading to decreased IRF6 expression, indicating that this genetic alteration may be a key factor in the mechanism causing CP.
Article Synopsis
- Low drug adherence significantly hampers the effectiveness of prescribed medications, making it crucial to understand the factors that lead to poor adherence and discontinuation of treatments.
- Analysis of data from over 1.8 million individuals reveals that socio-demographic factors, such as needing social assistance and immigration status, negatively impact medication adherence and persistence, while demographic and health factors show less consistent effects.
- Genetic factors show limited association with adherence, with some pharmacogenes linked to persistence; the study suggests that interventions targeting socio-economically disadvantaged populations could enhance medication uptake and overall health outcomes.
Article Synopsis
- In Finland, isolated cleft palate (CP) occurs more frequently than cleft lip with or without cleft palate (CL/P), which is the opposite trend seen in other European nations.
- A genome-wide association study identified a specific SNP (rs570516915) that is strongly linked to CP in the Finnish and Estonian populations.
- This SNP disrupts a binding site for the transcription factor IRF6, leading to decreased enhancer activity and impaired autoregulation, which may contribute to the increased risk of CP.
Short-term mortality risk, which is indicative of individual frailty, serves as a marker for aging. Previous age clocks focused on predicting either chronological age or longer-term mortality. Aging clocks predicting short-term mortality are lacking and their algorithmic fairness remains unexamined.
View Article and Find Full Text PDFThe percentage of people without children over their lifetime is approximately 25% in men and 20% in women. Individual diseases have been linked to childlessness, mostly in women, yet we lack a comprehensive picture of the effect of early-life diseases on lifetime childlessness. We examined all individuals born in 1956-1968 (men) and 1956-1973 (women) in Finland (n = 1,035,928) and Sweden (n = 1,509,092) to the completion of their reproductive lifespan in 2018.
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