Publications by authors named "S Juenger"
Background: Following surgery, patients with newly diagnosed glioblastoma frequently enter clinical trials. Nuanced risk assessment is warranted to reduce imbalances between study arms. Here, we aimed (I) to analyze the interactive effects of residual tumor with clinical and molecular factors on outcome and (II) to define a postoperative risk assessment tool.
View Article and Find Full Text PDFBackground: Resection of the contrast-enhancing (CE) tumor represents the standard of care in newly diagnosed glioblastoma. However, some tumors ultimately diagnosed as glioblastoma lack contrast enhancement and have a 'low-grade appearance' on imaging (non-CE glioblastoma). We aimed to (a) volumetrically define the value of non-CE tumor resection in the absence of contrast enhancement, and to (b) delineate outcome differences between glioblastoma patients with and without contrast enhancement.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the impact of re-resection on survival rates in patients with recurrent glioblastoma, using the RANO classification to assess the degree of tumor removal and its correlation with patient outcomes.
- A cohort of 681 patients was analyzed, revealing that re-resection generally leads to longer survival, especially when minimal residual contrast-enhancing tumor remains post-surgery.
- The findings support that "maximal resection" (class 2) offers better prognoses compared to "submaximal resection" (class 3), while "supramaximal resection" (class 1) does not improve survival and can result in postoperative complications.