The treatment of bacterial infections is hindered by the presence of biofilms and metabolically inactive persisters. Here, we report the synthesis of an enantiomeric block co-beta-peptide, poly(amido-D-glucose)-block-poly(beta-L-lysine), with high yield and purity by one-shot one-pot anionic-ring opening (co)polymerization. The co-beta-peptide is bactericidal against methicillin-resistant Staphylococcus aureus (MRSA), including replicating, biofilm and persister bacterial cells, and also disperses biofilm biomass.
View Article and Find Full Text PDFAim: To study the and anticandidal activity of nanocapsulated bovine lactoferrin.
Materials & Methods: and antimicrobial activities were conducted to study the anticandidal activities of nanocapsules (NCs).
Results: The NCs showed good anticandidal activities.
Lactoferrin has been known to have antimicrobial properties. This research was conducted to investigate the toxicity of Alginate/EUDRAGIT S 100-enclosed chitosan-calcium phosphate-loaded Fe-bLf nanocapsules (NCs) by in vitro and in vivo assays. Brine shrimp lethality assay showed that the LC value of NCs was more than 1mg/mL which indicated that NCs was not toxic to Brine shrimp.
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