Publications by authors named "S Jothy"

The treatment of bacterial infections is hindered by the presence of biofilms and metabolically inactive persisters. Here, we report the synthesis of an enantiomeric block co-beta-peptide, poly(amido-D-glucose)-block-poly(beta-L-lysine), with high yield and purity by one-shot one-pot anionic-ring opening (co)polymerization. The co-beta-peptide is bactericidal against methicillin-resistant Staphylococcus aureus (MRSA), including replicating, biofilm and persister bacterial cells, and also disperses biofilm biomass.

View Article and Find Full Text PDF

Aim: To study the and anticandidal activity of nanocapsulated bovine lactoferrin.

Materials & Methods: and antimicrobial activities were conducted to study the anticandidal activities of nanocapsules (NCs).

Results: The NCs showed good anticandidal activities.

View Article and Find Full Text PDF

Lactoferrin has been known to have antimicrobial properties. This research was conducted to investigate the toxicity of Alginate/EUDRAGIT S 100-enclosed chitosan-calcium phosphate-loaded Fe-bLf nanocapsules (NCs) by in vitro and in vivo assays. Brine shrimp lethality assay showed that the LC value of NCs was more than 1mg/mL which indicated that NCs was not toxic to Brine shrimp.

View Article and Find Full Text PDF