siRNA Treatment Enhances Collagen Fiber Formation in Tissue-Engineered Meniscus via Transient Inhibition of Aggrecan Production.

The complex collagen network of the native meniscus and the gradient of the density and alignment of this network through the meniscal enthesis is essential for the proper mechanical function of these tissues. This architecture is difficult to recapitulate in tissue-engineered replacement strategies. Prenatally, the organization of the collagen fiber network is established and aggrecan content is minimal.

Impact of Social Determinants of Health on Cancer Treatment Referrals in Patients Living with HIV in the United States: A Narrative Review.

Introduction: This narrative review aims to identify and explore the social determinants that prevent people living with HIV (PWH) from accessing specialized cancer centers in the United States and compare to patient experiences in other countries.

Methods: The review includes randomized controlled trials, cohort studies, case-control studies, qualitative studies, case series, and non-peer reviewed articles. The risk of bias was assessed using standardized tools, and data were synthesized narratively due to the heterogeneity of study designs and outcomes.

SspA is a transcriptional regulator of CRISPR adaptation in E. coli.

The CRISPR integrases Cas1-Cas2 create immunological memories of viral infection by storing phage-derived DNA in CRISPR arrays, a process known as CRISPR adaptation. A number of host factors have been shown to influence adaptation, but the full pathway from infection to a fully integrated, phage-derived sequences in the array remains incomplete. Here, we deploy a new CRISPRi-based screen to identify putative host factors that participate in CRISPR adaptation in the Escherichia coli Type I-E system.

Cost evaluation of acute ischemic stroke in Latin America: a multicentric study.

Background: Current literature highlights a gap in precise stroke cost data for Latin America. This study measures the real costs associated with acute ischemic stroke care in Latin America using Time-Driven Activity-Based Costing (TDABC). The findings aim to lay a solid foundation for adopting value-based healthcare (VBHC) strategies in the region.

Predictors of Long COVID Among Symptomatic US Adults Testing Positive for SARS-CoV-2 at a National Retail Pharmacy.

Background: Long COVID remains a significant public health concern. This study investigated risk factors for long COVID in outpatient settings.

Methods: A US-based prospective survey study (clinicaltrials.