Publications by authors named "S Joksaite"
Objectives: To evaluate and compare medication adherence and persistence for patients newly initiating single-inhaler triple therapy (SITT) and multiple-inhaler triple therapy (MITT) for chronic obstructive pulmonary disease (COPD) in Japan.
Design: Retrospective, new-user, active comparator, observational cohort study using inverse probability of treatment weighting.
Setting: Health insurance claims data from the Medical Data Vision Co.
Article Synopsis
- The study investigated the prevalence of eosinophilic granulomatosis with polyangiitis (EGPA) in Japan and analyzed the use of oral corticosteroids (OCS) before and after the approval of mepolizumab in 2018.
- The data showed that EGPA prevalence increased significantly from 2005 to 2020, while the median OCS dose and percentage of patients requiring higher doses decreased during the same period.
- Additionally, there was a reduction in relapses and hospitalizations among EGPA patients following the introduction of mepolizumab, indicating improved disease management.
Purpose: Improved hypereosinophilic syndrome (HES) ascertainment in electronic health record (EHR) databases may improve disease understanding and management. An algorithm to ascertain and characterize this rare condition was therefore developed and validated.
Methods: Using the UK clinical practice research datalink (CPRD)-Aurum database linked to the hospital episode statistics database (Admitted Patient Care data) from Jan 2012 to June 2019, this cross-sectional study ascertained patients with a specific HES code (index).
Purpose: Inhaled triple therapy is recommended for patients with chronic obstructive pulmonary disease (COPD) who have poorly controlled symptoms and to reduce the risk of exacerbations. This study assessed the clinical characteristics of new users of single- and multiple-inhaler triple therapy (SITT and MITT) treated in a primary care setting in England.
Patients And Methods: This cross-sectional, observational study used data from an electronic health record database (CPRD Aurum) of COPD patients registered with a primary care practice in England, with linkage to a secondary care database.