Anti-cobra venom activity of plant Andrographis paniculata and its comparison with polyvalent anti-snake venom.

Background: To investigate the anti-cobra venom effect of alcoholic extract of Andrographis paniculata.

Materials And Methods: After calculating the LD(99) of snake venom, the venom-neutralizing ability of plant extract at the dose 1 g/kg and 2 g/kg was determined using in vitro and in vivo methods. The alleviation in the mean survival time of the animals were used to infer the antivenom property of the drug after challenging with LD(99) of snake venom.

Partial in vitro and in vivo red scorpion venom neutralization activity of Andrographis paniculata.

Objective: Red scorpion (Mesobuthus tamulus) is the most lethal among all poisonous species of scorpions. Envenoming by Mesobuthus tamulus is quite common along the western coast of India, without any established therapy. Andrographis paniculata is one of the plants that has long been used in traditional herbal medicine for the treatment of poisoning by animal bites.

Effect of metoclopramide on peristalsis and antiperistalsis in isolated frog stomach and guinea-pig ileum.

The action of metoclopramide was studied on peristaltic as well as antiperistaltic activity in frog stomach and guinea-pig ileum. It was observed that metoclopramide enhances normal peristaltic activity by acting on dopamine-receptors whereas it inhibits antiperistalsis by some unknown mechanism. It is, therefore, inferred that inhibition of antiperistaltic activity might be an additional mechanism for its antiemetic effect.