Single monoiodoacetic acid injection reveals toll-like receptor, oestrogen, oxidative stress, and altered energy metabolism as key drivers of temporomandibular joint osteoarthritis in female rats.

Objectives: This study aimed to establish a reproducible and minimally invasive rat model of temporomandibular joint osteoarthritis (TMJ-OA) using intra-articular monoiodoacetic acid (MIA) injection, and to investigate the pathological mechanisms underlying TMJ-OA development, aimed at providing insights for potential clinical treatments.

Design: We compared the effects of single versus multiple MIA injections on body weight, pain behaviour, and condylar pathology in female Sprague-Dawley rats. We longitudinally assessed the progression of TMJ-OA over 5 weeks by evaluating condylar pathology and immunohistochemical staining.

Silicon alleviates aluminum-induced inhibition of photosynthetic and growth attributes in rice by modulating competitive pathways between ethylene and polyamines and activating antioxidant defense.

Silicon (Si) has been reported to mitigate aluminium (Al) toxicity in rice; however, the mechanism underlying this beneficial effect has not been fully elucidated. In this study, Si addition increased the total level of both free and conjugated putrescine (Put) content in rice leaves by 89.3 % through up-regulation of the key synthesis genes in both of arginine decarboxylase (ADC) and ornithine decarboxylase (ODC) pathways under Al stress.

SNet: Self-adaptive weighted fusion and self-adaptive aligned network for multi-modal MRI segmentation.

Background: Accurate segmentation of lesions is beneficial for quantitative analysis and precision medicine in multimodal magnetic resonance imaging (MRI).

Purpose: Currently, multimodal MRI fusion segmentation networks still face two main issues. On one hand, simple feature concatenation fails to fully capture the complex relationships between different modalities, as it overlooks the importance of dynamically changing feature weights across modalities.

Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury.

Myocardial ischemia/reperfusion (I/R) injury is a major contributor to myocardial damage, leading to adverse cardiac remodeling and dysfunction. Recent studies have highlighted the potential of gut microbiota-derived metabolites in modulating cardiac outcomes. Here, the cardioprotective effects of a commensal bacterium Flavonifractor plautii (F.

DiatOmicBase: a versatile gene-centered platform for mining functional omics data in diatom research.

Diatoms are prominent microalgae found in all aquatic environments. Over the last 20 years, thanks to the availability of genomic and genetic resources, diatom species such as Phaeodactylum tricornutum and Thalassiosira pseudonana have emerged as valuable experimental model systems for exploring topics ranging from evolution to cell biology, (eco)physiology, and biotechnology. Since the first genome sequencing projects initiated more than 20 years ago, numerous genome-enabled datasets have been generated, based on RNA-Seq and proteomics experiments, epigenomes, and ecotype variant analysis.