This study aimed to assess the interactive effects of CO-driven acidification, temperature rise, and PAHs toxicity on meiobenthic communities. Laboratory microcosms were established in a full factorial experimental design, manipulating temperature (25 °C and 27 °C), pH (8.1 and 7.
View Article and Find Full Text PDFOcean noise generated by human activities at sea has been increasing over the decades, affecting marine ecosystems. Ship traffic flow between the Mediterranean or South Atlantic and northern Europe makes the coast of Portugal one of the most intense shipping highways on a global scale. Among the cetaceans of the coast of Portugal, the common dolphin (Delphinus delphis) was selected as a target species.
View Article and Find Full Text PDFCortical hypometabolism on FDG-PET is a well-established neuroimaging biomarker of cognitive impairment in Parkinson's disease (PD), but its pathophysiologic origins are incompletely understood. Cholinergic basal forebrain (cBF) degeneration is a prominent pathological feature of PD-related cognitive impairment and may contribute to cortical hypometabolism through cholinergic denervation of cortical projection areas. Here, we investigated in-vivo associations between subregional cBF volumes on 3T-MRI, cortical hypometabolism on [F]FDG-PET, and cognitive deficits in a cohort of 95 PD participants with varying degrees of cognitive impairment.
View Article and Find Full Text PDFBackground: Parkinson's disease (PD) therapeutic strategies have evolved since levodopa introduction in mid 1900s. To understand their impact and research gaps, this study delineated the clinical progression of PD in recent years.
Methods: Using Accelerating Medicine Partnership-PD (AMP-PD) data harmonized from seven biomarker discovery studies (2010-2020), we extracted: overall [Schwab and England (S&E), PD Questionnaire (PDQ-39)]; motor [Movement Disorders Society Unified PD Rating Scale (MDS-UPDRS)-II and -III and Hoehn & Yahr (HY)]; and non-motor [MDS-UPDRS-I, University of Pennsylvania Smell Identification Test (UPSIT), Montreal Cognitive Assessment (MoCA), and Epworth Sleepiness Scale (ESS)] scores.