Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration.

Introduction: Bacterial infection of the intervertebral disc can lead to vertebral endplate edema known as Modic changes, with associated chronic low back pain. Oral antimicrobial therapy has shown efficacy but relies on prolonged dosing and may not be optimal in terms of patient outcome, side effects, or antibiotic stewardship. There is no antibiotic formulation approved for intradiscal administration.

Sustainable municipal solid waste management: A comparative analysis of enablers and barriers to advance governance in the Arctic.

Despite the proliferation of studies on waste governance over the past decades, comparative research on advancing sustainable municipal solid waste management (MSWM) in medium-sized cities across various political regimes and remote geographies has been overlooked. Comprehending factors for governance advancement is critical for Arctic cities, as they face unique challenges due to their geographical remoteness, population size, economic constraints, and severe weather conditions. This qualitative study, drawn from the cases of Anchorage (USA), Murmansk (Russia), and Tromsø (Norway), uses Evolutionary Governance Theory (EGT) to examine how dependencies between actors and institutions enable and create barriers to the advancement of MSWM.

Biopsychosocial intervention for stroke carers (BISC): results of a feasibility randomised controlled trial and nested qualitative interview study.

Objective: To determine the feasibility of recruiting to and delivering a biopsychosocial intervention for carers of stroke survivors.

Design: Feasibility randomised controlled study with nested qualitative interview study.

Setting: The intervention was delivered in the community in either a group or one-to-one format.

Time-kill kinetics of cadazolid and comparator antibacterial agents against different ribotypes of Clostridium difficile.

Purpose: Clostridium difficile infection (CDI) is an increasing cause of nosocomial diarrhoea worldwide, which has been partly attributed to the emergence of hypervirulent strains including C. difficile BI/NAP1/ribotype 027 and BK/NAP7/ribotype 078. Cadazolid is a new antibiotic currently in late-stage clinical studies for the treatment of CDI.

Potentiation of Antibiotic Activity by a Novel Cationic Peptide: Potency and Spectrum of Activity of SPR741.

Novel approaches for the treatment of multidrug-resistant Gram-negative bacterial infections are urgently required. One approach is to potentiate the efficacy of existing antibiotics whose spectrum of activity is limited by the permeability barrier presented by the Gram-negative outer membrane. Cationic peptides derived from polymyxin B have been used to permeabilize the outer membrane, granting antibiotics that would otherwise be excluded access to their targets.