Investigation of immunotoxicity of supercypermethrin forte in the Wistar rat.

The study was done to find out whether subacute exposure to supercypermethrin forte (SCM) affected cellular and humoral immunity. Groups of 10 male Wistar rats were given SCM by gavage for 28 days at 12.5 mg kg-1 day-1 (1/14 LD50), 8.

Immunological consequences of burn injury in children.

The authors investigated immunological changes after burn injury in children. Relevant findings were observed in the following immunological factors: phagocytose activity, T-lymphocytes, active T-lymphocytes, test of blastic transformation of lymphocytes and immunoglobulins. The findings confirm from an immunological point of view the requirement of early necrectomy (at the latest on day 4 or 5 after injury).

[Treatment of nephrotic syndrome with cyclosporin A].

The authors treated eight children with corticoid dependent syndrome caused by minor abnormalities of the glomeruli with Cyclosporin A. They administered Cyclosporin, 5 mg/kg/24 h., for a period of 8-16 weeks.

Immunological markers in patients with different forms of viral hepatitis B treated by "conventional" therapy or with HuIFN alpha.

Selected immunological, biochemical, and other viral hepatitis B (VH-B) markers were followed and analysed during "conventional" or human interferon alpha (HuIFN alpha) therapy of patients with different forms of VH-B. The immunological data obtained from "conventionally"-treated acute hepatitis B (AH-B), prolonged acute hepatitis B (AH-BP) or chronic active hepatitis B (CAH-B) patients disclosed differences unsatisfactory for comparison of the influence of HuIFN alpha therapy on changes of the immunological markers. More valuable data were obtained through continuous registration of the dynamics of selected blood markers.

Transient increase of HBsAg levels following human IFN alpha treatment signalises the patient's response in chronic active hepatitis B.

Eleven patients in early stages of chronic active hepatitis B (CAH-B) were treated for weeks or months with a natural or recombinant human interferon alpha (Hu IFN alpha). Changes of serum levels of selected hepatitis B virus (HBV) markers were observed after Hu IFN alpha administration. Increase of HBsAg level accompanied by more or less simultaneous HBeAg level depression was the most interesting observation.