Whole blood glycerophospholipids in dried blood spots - a reliable marker for the fatty acid status.

Background: Whole blood total fatty acid analysis in capillary blood has recently been proposed for fatty acid status determination, but the accuracy of this method is affected by the fast turnover of triaclyglyceride (TAG) fatty acids, the individual hematocrit and postprandial state.

Method: An established method for the glycerophospholipid (GPL) analysis in plasma was adapted for the analysis of whole blood GPL and tested in a fat challenge test. Blood samples were collected from nine participants after receiving a standardised breakfast containing 42g of sunflower oil.

Smooth muscle contraction and growth of stromal cells in the human prostate are both inhibited by the Src family kinase inhibitors, AZM475271 and PP2.

Background And Purpose: In benign prostatic hyperplasia, increased prostate smooth muscle tone and prostate volume may contribute alone or together to urethral obstruction and voiding symptoms. Consequently, it is assumed there is a connection between smooth muscle tone and growth in the prostate, but any molecular basis for this is poorly understood. Here, we examined effects of Src family kinase (SFK) inhibitors on prostate contraction and growth of stromal cells.

Oxidative C-H bond functionalization and ring expansion with TMSCHN2 : a copper(I)-catalyzed approach to dibenzoxepines and dibenzoazepines.

Tricyclic dibenzoxepines and dibenzazepines are important therapeutic agents for the pharmaceutical industry and academic research. However, their syntheses are generally rather tedious, requiring several steps that involve a Wagner-Meerwein-type rearrangement under harsh conditions. Herein, we present the first copper(I)-catalyzed oxidative CH bond functionalization and ring expansion with TMSCHN2 to yield these important derivatives in a facile and straightforward way.

Phase behavior and molecular packing of octadecyl phenols and their methyl ethers at the air/water interface.

Noncovalent molecular interactions, such as hydrogen bonding and van der Waals forces, play an important role in self-assembling to supramolecular structures. To study these forces, we chose monolayers at the air/water interface to limit the possible arrangements of the interacting molecules. Furthermore, monolayers provide useful tools to understand and study interactions between molecules in a controlled and fundamental way.

Tetraaryl tetradecahydroporphyrazins: novel porphyrin derivatives featuring a cyclic benzene-ring tetramer.

Treatment of tetramethylsuccinonitrile 1 with aryl lithium compounds and subsequent quenching with chlorotrimethylsilane yields 5-aryl-3,3,4,4-tetramethyl-N-(trimethylsilyl)-3,4-dihydropyrrol-2-imines 2 a-c in 49-71% yield. Attempts to crystallise 2 a-c in the presence of wet air yielded the tetraaryl tetradecahydroporphyrazins 3 a-c in yields of 4-84% as single diastereomers. X-ray diffraction studies of 3 b and c showed that only the isomer with four aryl substituents pointing in the same direction was formed.