Publications by authors named "S James Adelstein"
Sacral neuromodulation (SNM) is an effective third-line therapy for overactive bladder (OAB). COVID-19 may have a temporary negative effect on SNM function. We describe two cases of increased sensory thresholds and loss of SNM efficacy following COVID-19 infection.
View Article and Find Full Text PDFObjective: To qualitatively assess the perception and experiences of bladder instillation for interstitial cystitis among women on Reddit, a widely used anonymous social media platform.
Methods: "r/interstitialcystitis," a Subreddit with >27,000 subscribers, was queried for bladder instillation among women with interstitial cystitis in November 2023. Posts were analyzed qualitatively by 3 independent researchers.
Article Synopsis
- This study looked at urinary incontinence (UI) in patients who had surgery for a prostate condition called BPH.
- Out of over 274,000 patients treated, about 11,000 had ongoing UI a year after their surgery.
- Some types of surgeries had higher chances of causing UI, like HoLEP and PVP, while others like Prostatic Artery Embolization had much lower rates of this problem.
Introduction: Urinary tract infections (UTIs) are a leading cause of infection in adults. The most common cause is gastrointestinal bacteria ascending the urethra into the bladder. Studies showing fecal incontinence (FI) is a risk factor for UTI have been limited to nursing home populations.
View Article and Find Full Text PDFBackground Aims: Several anti-mesothelin (MSLN) chimeric antigen receptor (CAR) T cells are in phase 1/2 clinical trials to treat solid-organ malignancies. The effect of MSLN antigen density on MSLN CAR cytotoxicity against tumor cells has not been examined previously, nor are there data regarding the effect of agents that increase MSLN antigen density on anti-MSLN CAR T cell efficacy.
Methods: MSLN antigen density was measured on a panel of pancreatic cancer and mesothelioma cell lines by flow cytometry.