Publications by authors named "S Jamaly"
Aims: To assess the long-term risk of developing type 2 diabetes in patients with obesity who have undergone gastric bypass surgery compared to non-operated patients with obesity and the general population.
Methods: This study included 71,495 patients aged 20-65 years with a principal diagnosis of obesity in the Swedish Patient Register in 2001-2013. Of these, 23,099 had undergone gastric bypass and 32,435 had not.
Importance: Currently, predictive biomarkers for response to immune checkpoint inhibitor (ICI) therapy in lung cancer are limited. Identifying such biomarkers would be useful to refine patient selection and guide precision therapy.
Objective: To develop a machine-learning (ML)-based tumor-infiltrating lymphocytes (TILs) scoring approach, and to evaluate TIL association with clinical outcomes in patients with advanced non-small cell lung cancer (NSCLC).
Aim: We aim to assess the risk of heart failure in patients with obesity with and without gastric bypass surgery compared with population controls.
Methods And Results: This cohort study included all patients aged 20-65 years with a first ever registered principal diagnosis of obesity in the Swedish Patient Register in 2001-2013. These patients were matched by age, sex, and region with two population controls from the general Swedish population without obesity diagnosis.
Article Synopsis
- Kidney involvement in systemic lupus erythematosus (SLE) leads to serious health issues, primarily through lupus nephritis (LN) which is driven by various autoimmune mechanisms affecting kidney cells.
- The process of kidney damage involves interactions between different cell types, including podocytes and macrophages, influenced by cytokines and autoantibodies, which contribute to injury and inflammation.
- Tertiary lymphoid structures in the kidneys, which resemble germinal centers, are linked to worse outcomes in lupus nephritis, and understanding their formation may help identify therapeutic targets to mitigate kidney damage.
Acute and chronic kidney failure is common in hospitalized patients with COVID-19, yet the mechanism of injury and predisposing factors remain poorly understood. We investigated the role of complement activation by determining the levels of deposited complement components (C1q, C3, FH, C5b-9) and immunoglobulin along with the expression levels of the injury-associated molecules spleen tyrosine kinase (Syk), mucin-1 (MUC1) and calcium/calmodulin-dependent protein kinase IV (CaMK4) in the kidney tissues of people who succumbed to COVID-19. We report increased deposition of C1q, C3, C5b-9, total immunoglobulin, and high expression levels of Syk, MUC1 and CaMK4 in the kidneys of COVID-19 patients.
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