Publications by authors named "S Jacquot Barreau"
Article Synopsis
- The study aimed to create an in vitro model of chronic myeloid leukemia (CML) progression, focusing specifically on the blast crisis stage, to discover new treatment targets.
- Researchers mutagenized different CML-derived induced pluripotent stem cell (iPSC) lines using the alkylating agent ENU, examining their properties after 12 days of hematopoietic differentiation, including their gene expression.
- Results showed that one mutated iPSC line produced myeloid blasts with specific markers and displayed a delayed differentiation compared to controls, highlighting CD25 as a potential marker for CML progression in patients.
Although anti-CD38 monoclonal antibodies have improved the prognosis of relapsed/refractory multiple myeloma (RRMM), some patients still experience early relapses with poor outcomes. This present study evaluated the predictive value of FDG PET/CT parameters for RRMM prior to initiating anti-CD38 treatment. We included 38 consecutive RRMM patients who underwent a PET/CT scan treated at our institution at relapse.
View Article and Find Full Text PDFPrecise classification of acute leukemia (AL) is crucial for adequate treatment. EuroFlow has previously designed an AL orientation tube (ALOT) to guide toward the relevant classification panel and final diagnosis. In this study, we designed and validated an algorithm for automated (database-supported) gating and identification (AGI tool) of cell subsets within samples stained with ALOT.
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