Publications by authors named "S Jaatinen"
Article Synopsis
- The study focuses on the progression of low-grade diffuse astrocytomas into grade 4 tumors and its impact on patient outcomes, highlighting the need for better understanding to enhance patient care.
- Researchers analyzed genetic data from a cohort of patients with IDH-mutant astrocytomas, revealing significant alterations like increased chromosomal rearrangements and inactivation of key genes related to cell cycle regulation after treatment.
- Results indicate that combined postoperative radiation and chemotherapy, especially temozolomide, may lead to improved survival outcomes, particularly in patients with grade 3 tumors, suggesting a need for more effective treatment strategies.
Article Synopsis
- - The study examines the genomic heterogeneity of prostate cancer and its impact on treatment resistance, suggesting that incorporating evolutionary principles into clinical trials could provide valuable insights for therapy strategies.
- - Researchers analyzed whole genome data and 3D anatomical structures from two patients with high-risk prostate cancer, using advanced tools to map tumor origins, genetic mutations, and metastasis patterns.
- - Results indicate that specific mutations and evolutionary patterns significantly influence cancer progression and metastasis, highlighting the potential for evolutionary analysis to inform therapy choices in prostate cancer patients.
Oligodendrogliomas are typically associated with the most favorable prognosis among diffuse gliomas. However, many of the tumors progress, eventually leading to patient death. To characterize the changes associated with oligodendroglioma recurrence and progression, we analyzed two recurrent oligodendroglioma tumors upon diagnosis and after tumor relapse based on whole-genome and RNA sequencing.
View Article and Find Full Text PDFOvarian cancer has the highest mortality rate of all gynecologic malignancies. Identification of new biomarkers is highly needed due to its late diagnosis and high recurrence rate. The objective of this study was to identify mechanisms of therapy resistance and potential biomarkers by analyzing mRNA and protein expression from samples derived from patients with platinum-sensitive and -resistant ovarian cancer (total cohort n = 53).
View Article and Find Full Text PDFThe behaviour of pharmaceuticals related to the human immunodeficiency virus treatment was studied in the liquid phase of source-separated urine during six-month storage at 20°C. Six months is the recommended time for hygienization and use of urine as fertilizer. Compounds were spiked in urine as concentrations calculated to appear in urine.
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