Publications by authors named "S JICK"
The risk of acute infection in association with first ever diagnosed depression: a cohort study.
Soc Psychiatry Psychiatr Epidemiol
November 2024
Article Synopsis
- The study aimed to evaluate the risk of acute infections in patients recently diagnosed with depression versus those without a depression diagnosis, using a large primary-care database from the UK.
- The cohort study included nearly 286,000 patients with diagnosed depression and a matched group without depression, looking at rates of various acute infections over two years.
- Results indicated that patients with depression had a slightly higher rate of acute infections (97.3 vs. 83.7 per 1,000 person-years), but this increase was not significant when controlling for other health factors, suggesting that depression alone doesn’t markedly raise infection risk.
Unlabelled: Osteonecrosis of the jaw (ONJ) is an adverse effect of antiresorptives. Among female patients treated for osteoporosis, ONJ risk was threefold higher after 2-3 years of treatment and eightfold after 10 years compared with past use. Absolute risks remained low (~ 0.
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- A study examined whether statins, commonly prescribed for high cholesterol and heart risk, can help prevent venous thromboembolism (VTE) in adults aged 40-79 with hyperlipidemia.
- The research included data from over 166,000 patients and used various statistical methods to compare the occurrence of VTE between those using statins and those using fibrates (another cholesterol-lowering medication).
- Results indicated a potential protective effect of statins against unprovoked VTE, with differing levels of significance across the statistical analyses used.
Background: Preclinical studies suggested that drugs that functionally inhibit acid sphingomyelinase (FIASMA)may enhance immune cell longevity and potentially offer protection against infections. Many antidepressants have shown FIASMA activity.
Methods: We conducted a cohort study using primary-care data from the UK-based Clinical Practice Research Datalink (2000-2021).
Purpose: We describe constructs designed to protect the integrity of the results from comparative analyses using real-world data (RWD): staging and clean room.
Methods: Staging involves performing sequential preliminary analyses and evaluating the population size available and potential bias before conducting comparative analyses. A clean room involves restricted access to data and preliminary results, policies governing exploratory analyses and protocol deviations, and audit trail.