Associations between subclinical thyroid dysfunction and cardiovascular risk factors according to age and sex.

Context: Subclinical thyroid dysfunction (ScTD) comprising subclinical hypothyroidism (SHypo) and subclinical hyperthyroidism (SHyper) has been associated with increased risk for cardiovascular events.

Objective: To assess associations between ScTD and cardiovascular risk factors (cvRFs) according to age and sex.

Design And Setting: Pooled individual participant data analysis of large prospective cohort studies from the Thyroid Studies Collaboration.

Effects of tattoos on the aesthetic appreciation of human stimuli as influenced by expertise, tattoo status, and age reflecting internalized social norms.

Scientific interest in body modifications continues to grow, and tattoos have recently become a subject of empirical aesthetics. While conceptual structures of tattoo aesthetics have been studied, the question of how tattoos are aesthetically appreciated has not yet been studied. In this study, we examined how tattoos influence the aesthetic appreciation of human stimuli and uncovered differences in beauty perceived by individuals older and younger than 50, which we consider indicative of different internalized social norms, experts (tattoo artists) and nonexperts, and tattooed and nontattooed individuals.

[Drug-drug interactions in critically ill patients].

Critically ill patients are at high risk of adverse drug-drug interactions. Pharmacodynamic drug-drug interaction may cause organ damage. Pharmacokinetic interactions are usually caused by inhibition or induction of enzymes of drug metabolism such as cytochrome P-450 isoenzymes or transporter proteins such as P‑glycoprotein.

Fracture-Related Safety Reporting of JAK Inhibitors: An Analysis from the WHO Global VigiBase.

Introduction: The Janus kinase (JAK) inhibitors are treatment options for autoimmune diseases. Numerous safety concerns have been raised. The European Medicines Agency updated the product information of tofacitinib to include the risk of fractures-but not for other JAK inhibitors.

Mechanical thrombectomy failure in anterior and posterior circulation stroke: current results from a high-volume comprehensive center.

Background: Mechanical thrombectomy (MT) is an established therapy for acute ischemic stroke (AIS), but recanalization is not always achieved. Common reasons are inadequate removal at the thrombus site and difficulties with the access route. In order to identify risk factors for MT failure we conducted a retrospective study on a high-volume comprehensive stroke center.