Publications by authors named "S J Warrillow"
Introduction: Paracetamol (acetaminophen)-induced acute liver failure (ALF) with severe hyperammonemia (ammonia >100 µmol⋅L-1) is a life-threatening condition. A strategy based on high-intensity continuous renal replacement therapy (CRRT) without early (up to day seven) transplantation may enable clinicians to safely identify which patients can recover and survive and which patients require transplantation.
Methods: We conducted a single-center, retrospective cohort study of patients with severely hyperammonemic paracetamol-induced ALF.
Background: An optimal pharmacological strategy for fast-track cardiac anesthesia (FTCA) is unclear. This study evaluated the effectiveness and safety of an FTCA program using methadone and non-opioid adjuvant infusions (magnesium, ketamine, lidocaine, and dexmedetomidine) in patients undergoing coronary artery bypass grafting.
Methods: This retrospective, multicenter observational study was conducted across private and public teaching sectors.
Article Synopsis
- - The study aimed to assess the safety and effectiveness of a direct enteral challenge for critically ill patients with low-risk penicillin allergy labels, as many of these labels could be incorrect and may limit treatment options.
- - In a trial involving 533 screened patients, 80 were enrolled, with 40 randomly assigned to the challenge group, revealing a low positive challenge rate of just 2.5% and no serious adverse events reported.
- - Results indicate that direct enteral challenges are a safe and valid method for evaluating penicillin allergies in ICU patients, suggesting that broader eligibility and routine allergy assessments could improve treatment protocols in critical care settings.
Background: Noradrenaline and metaraminol are commonly used vasopressors in critically ill patients. However, little is known of their dose equivalence.
Methods: We conducted a single centre retrospective cohort study of all ICU patients who transitioned from metaraminol to noradrenaline infusions between August 26, 2016 and December 31, 2020.