Publications by authors named "S J Vervoort"
Article Synopsis
- Therapeutic strategies focusing on disrupting dysregulated transcription have shown promise for treating cancers like leukaemias using small molecule inhibitors that target key proteins involved in gene expression.* -
- Research indicates that the effectiveness of these inhibitors is influenced not just by their ability to stop mRNA production, but also by how quickly mRNA is produced and degraded.* -
- Findings suggest that modifying post-transcriptional processes, such as targeting specific proteins, can enhance the effects of transcriptional inhibitors, offering potential new combination therapies for leukaemia.*
Interviewing people on sensitive topics: challenges and strategies.
Eur J Cardiovasc Nurs
September 2024
Interviewing participants on sensitive topics is challenging and requires carefully planned and executed strategies throughout the research process. Sensitive topics have the potential to cause distress to participants or researchers. In this methods paper, strategies for conducting interviews on sensitive topics are described, including choosing the appropriate interview approach, creating a safe and comfortable environment, building rapport, utilizing sensitive and open questioning, reflexivity of the researcher, and awareness of the potential therapeutic effect of the interviews on participants.
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- Tumours evade immune responses, making cancer immunotherapies less effective, mainly through loss of antigen presentation and cytokine signaling pathways.
- A genome-wide CRISPR/Cas9 screen identified that loss of core-binding factor subunit beta (CBFβ) increases tumour resistance to CAR-T cells, which do not rely on traditional antigen presentation.
- The study found that intracellular zinc levels influence tumour cell susceptibility to T cell killing, suggesting that targeting zinc could enhance the effectiveness of cancer therapies in overcoming immune evasion.
Insight into patients' personal values, wishes, and needs (VWN) by clinicians is essential to guide appropriate palliative care. To gain insight into the exploration and monitoring of the VWN of patients with advanced cancer during the illness trajectory by hospital oncology clinicians. A generic qualitative study was conducted from February 2022 to July 2022.
View Article and Find Full Text PDFVariants in the poorly characterised oncoprotein, MORC2, a chromatin remodelling ATPase, lead to defects in epigenetic regulation and DNA damage response. The C-terminal domain (CTD) of MORC2, frequently phosphorylated in DNA damage, promotes cancer progression, but its role in chromatin remodelling remains unclear. Here, we report a molecular characterisation of full-length, phosphorylated MORC2, demonstrating its preference for binding open chromatin and functioning as a DNA sliding clamp.
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