Publications by authors named "S J Van Laere"
Article Synopsis
- Metastatic behavior in liver-metastatic colorectal cancer (CRC) varies significantly based on histopathological growth patterns (HGPs), influencing treatment outcomes, with desmoplastic HGP being linked to favorable and replacement HGP to unfavorable outcomes.
- Understanding cellular and molecular factors of these growth patterns is crucial for improving cancer biology knowledge and designing effective clinical trials.
- Analysis of tumor tissue reveals that HGPs are influenced by epigenetic factors rather than specific gene mutations, with distinct gene expression differences reflecting cancer biology themes, such as inflammation for desmoplastic and cell proliferation for replacement patterns.
Background: Neoadjuvant chemotherapy (NACT) became a standard treatment strategy for patients with inflammatory breast cancer (IBC) because of high disease aggressiveness. However, given the heterogeneity of IBC, no molecular feature reliably predicts the response to chemotherapy. Whole-exome sequencing (WES) of clinical tumor samples provides an opportunity to identify genomic alterations associated with chemosensitivity.
View Article and Find Full Text PDFBackground And Aims: Mucosal healing is considered as a key therapeutic endpoint in inflammatory bowel diseases (IBD) and comprises endoscopic improvement of inflammation without taking barrier healing into account. Mucins are critical components of the mucosal barrier function that give rise to structurally diverse isoforms. Unraveling disease-associated mucin isoforms that could act as an indication for barrier function would greatly enhance IBD management.
View Article and Find Full Text PDFTherapeutic resistance presents a significant hurdle in combating inflammatory breast cancer (IBC), adding to the complexity of its management. To investigate these mechanisms, we conducted a comprehensive analysis using transcriptomic and proteomic profiling in a preclinical model alone with correlates of treatment response in IBC patients. This included SUM149 cell lines derived from treatment-naïve patients, along with acquired drug resistance (rSUM149) and others in a state of resistance reversal (rrSUM149), aiming to uncover drug resistance networks.
View Article and Find Full Text PDFBackground: Inflammatory breast cancer (IBC) is the most pro-metastatic form of BC. Better understanding of its enigmatic pathophysiology is crucial. We report here the largest whole-exome sequencing (WES) study of clinical IBC samples.
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