Publications by authors named "S J Thurston"
Pregnant people are ubiquitously exposed to endocrine-disrupting phthalates through consumer products and food. The placenta may be particularly vulnerable to the adverse effects of phthalates, with evidence from animal models suggesting impacts on placental development and vascularization. We translate this research to humans, examining gestational exposure to phthalates and phthalate replacements in relation to novel markers of chorionic plate surface vascularization.
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- The study analyzed the relationship between certain types of particulate matter (PM) and hospitalizations or emergency visits for asthma and COPD in New York before and after implementing stricter automobile emission controls.
- Using statistical methods, it identified that increases in specific PM sources like spark-ignition emissions and secondary sulfates were linked to higher rates of asthma emergency visits, while diesel emissions had a negative association.
- After the new emission regulations were put in place, there was a decrease in COPD hospital admissions related to some PM sources, but asthma visits generally increased, highlighting the need for further investigation into these trends.
Benzo[]pyrene and phenanthrene hemoglobin adducts as biomarkers of longer-term air pollution exposure.
Environ Sci Process Impacts
November 2024
Article Synopsis
- The study examines PAH-hemoglobin adducts in blood samples from pregnant women in Rochester, NY, as potential long-term exposure biomarkers for air pollution.
- Researchers measured specific hydrolysis products of PAH-hemoglobin adducts (BaPT and PHET) and linked these to cumulative exposure to particulate matter (PM) during pregnancy.
- The results indicated positive correlations between these biomarker levels and PM exposure over specified gestational weeks, highlighting PAH-hemoglobin adducts as effective indicators of longer-term air pollution exposure, while no link was found with NO exposure.
Medical researchers are increasingly prioritizing the inclusion of underserved communities in clinical studies. However, mere inclusion is not enough. People from underserved communities frequently experience chronic stress that may lead to accelerated biological aging and early morbidity and mortality.
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